Figure 2. Click chemistry-mediated targeting of a drug surrogate to subcutaneous space.

Mice were injected with unconjugated control alginate hydrogels (left flank) or azide-conjugated hydrogels (right flank). Targeting to this gel was tested through i.v. injection of a fluorescently labeled DBCO. A) representative IVIS images, B) quantification of fluorescence at the gel site after 48 hours. Values represent the mean +/− SEM, n=3. p-value from Student’s two-tailed t-test (homoscedastic).