Table 3.
Summary of compartmental PK parameters for UNBS5162 by treatment group [Mean (SD)]
| Group | Dose (mg) | K10 (h−1) | Cmax (ng/mL) | t1/2 α (h) | t1/2 β (h) | AUC (h ng/mL) | CL (L/h) | Vss (L) |
|---|---|---|---|---|---|---|---|---|
| 1 | 30.2 | 0.632 (0.080) | 419.6 (146.2) | 0.51 (0.08) | 7.48 (2.29) | 958 (245) | 32.4 (5.3) | 206 (36) |
| 2 | 64.6 | 0.499 (0.251) | 612.6 (214.7) | 0.64 (0.21) | 8.19 (0.51) | 1644 (279) | 39.9 (6.2) | 313 (33) |
| 3 | 125.0 | 0.737 (0.240) | 1428.9 (643.7) | 0.42 (0.12) | 6.94 (1.67) | 3194 (1143) | 43.1 (16.9) | 280 (142) |
| 4 | 169.9 | 0.564 (0.154) | 1821.4 (893.6) | 0.63 (0.16) | 7.34 (0.91) | 4252 (1709) | 43.7 (14.1) | 278 (99) |
| 5 | 252.9 | 1.138 (0.370) | 3847.7 (738.5) | 0.33 (0.10) | 6.56 (1.04) | 6640 (2006) | 39.7 (6.7) | 202 (53) |
| 6 | 311.0 | 0.963 (0.322) | 3981.3 (1986.6) | 0.28 (0.03) | 7.57 (1.62) | 10127 (4411) | 35.1 (15.8) | 245 (109) |
| 7 | 433.7 | 1.352 (0.370) | 6376.6 (321.3) | 0.32 (0.06) | 6.78 (1.34) | 11631 (2161) | 37.6 (4.9) | 162 (45) |
| 8 | 491.2 | 1.075 (0.231) | 5913.7 (267.5) | 0.33 (0.02) | 7.94 (0.21) | 12786 (1852) | 39.2 (10.6) | 233 (31) |
K10 elimination rate, Cmax peak concentration, t1/2 α half-life associated with the rapid macro-rate constant alpha, t1/2 β half-life associated with the slow macro-rate constant beta, AUC area under the curve, CL total body clearance, Vss volume of distribution at steady state