Table 1.
Comparison between colorimetric, radioactive and fluorescent tracers
| Site of injection | Tracer | Study | N | Surgical approach | SLN detection rate overall (bilateral) | PA SLN detection Rate | Mean SLN per patient |
|---|---|---|---|---|---|---|---|
| Cervix | Blue | Mais et al. 2010 [48] | 34 | L,1 | 62% (NR) | NR | NR |
| Vidal et al. 2013 [56] | 66 | L,1 | 62% (35%) | 0% | 1.8 | ||
| Tanner et al. 2015 [36] | 57 | R | NR (46%) | NR | NR | ||
| Holloway et al, 2017 [37] | 200 | R | 76% (40%) | 2.5% | 2.8 | ||
| Total Blue | 357 | 71% (40%) | 1.9% | 2.6 (686/266) |
|||
| Technetium99 | Niikura et al. 2013 [49] | 45 | L | 96% (80%) | 0% | 3.1 | |
| Sawicki et al. 2015 [52] | 82 | L | 92% (67%) | 5% | 3.1 | ||
| Total Technetium99 | 127 | 93% (71%) | 3.2% | 3.1 | |||
| Blue & Technetium99 | Ballester et al. 2011 [30] | 125 | L,1 | 89% (62%) | 4% | 3 | |
| Barlin et al. 2012 [38] | 498 | L,1,R | 81% (51%) | 3% | 3 | ||
| How et. al 2012 [44] | 100 | R | 92% (66%) | 15% | 2 | ||
| Bats et al. 2013 [39] | 43 | L,1 | 70% (37%) | 0% | 2.9 | ||
| Lopez-de la Manzanara Cano et al 2014 [47] | 50 | L,1 | 92% (34%) | 7% | 1.5 | ||
| Desai et al. 2014 [41] | 120 | R | 86% (52%) | 0% | 2.6 | ||
| Touhami et al. 2015 [55] | 268 | L,1, R | 94% (74%) | NR | 2 | ||
| Total Blue & Technetium99 | 1,204 | 86% (57%) | 4.1% | 2.6 | |||
| ICG | Jewell et al. 2014 [32] | 227J | R | 95% (79%) | 10% | 3 | |
| Plante et al. 2015 [50] | 50p | l,R | 96% (88%) | 3% | 3 | ||
| Tanner et al. 2015 [36] | 54 | R | NR (77%) | NR | NR | ||
| Rossi et al. 2017 [64] | 340 | R | NR (52%) | 23% | 2 | ||
| TOTAL ICG | 671 | 95% (66%) | 12.7% | 2.4 | |||
| ICG & Technetium99 | Mucke et al. 2014 [58] | 31 | L,1 | 90% (52%) | 23% | 1.3 | |
| Blue & ICG & Technetium99 | How et al. 2015 [43] | 100 | R | 92% (76%) | 8% | 2.9 | |
| Blue & ICG | Holloway et al. 2017 [37] | 180 | R | 96% (84%) | 2.8% | 2.9 | |
| Total combinations with ICG | 311 | 94% (78%) | 6.4% | 2.7 (852/311) | |||
| TOTAL CERVIX | 2,670 | 87% (60%) | 5.8% | 2.8 | |||
| Hysterosco pic | Technetium99 | Solima et al. 2012 [53] | 59 | L,1 | 95% (NR) | 56% | 2.6 |
| Niikura et al. 2013 [49] | 55 | L | 78% (49%) | 56% | 2.8 | ||
| Favero et al. 2015 [42] | 42 | l | 73% (NR) | 40% | 1.7 | ||
| Blue & Technetium99 | Delaloye et al. 2007 [40] | 60 | L,1 | 82% (37%) | 27% | 3.7 | |
| TOTAL HYSTERO SCOPIC | 216 | 82% (42%) | 45% | 2.8 | |||
| Myometrial | Blue | Lopes et al. 2007 [46] | 40 | L | 78% (NR) | 35% | 1.6 |
| Li et al. 2007 [57] | 20 | L | 74% (45%) | 3% | 3.9 | ||
| Niikura et al. 2013 [49] | 51 | L | 63% (49%) | NR | 1.7 | ||
| Sawicki et al. 2015 [52] | 82 | L | 74% (44%) | 10% | 3 | ||
| Technetium99 | Tomé et al. 2013 [54] | 74 | l | 74% (19%) | 34% | 2.8 | |
| Blue & Technetium99 | Robova et al. 2009 [51] | 67 | L | 73% (NR) | NR | NR | |
| TOTAL MYOMET RIAL | 334 | 73% (37%) | 21% | 2.6 |
Abbreviations: n = number of patients, ICG= indocyanine green, SLN = sentinel lymph node, NR = not reported, L= laparotomy, l = laparoscopy, R = robotic, PA SLN= Percentage of detected Para-aortic SLNs.