Table 4.
Sex-stratified logistic regression models adjusted for Age for each outcome variable in symptomatic patients with IBS (clopidogrel vs. no-clopidogrel groups)
| Outcome variables (GI symptoms) | Females only adjusted for Age (clopidogrel vs. no-clopidogrel)
|
Males only adjusted for Age (clopidogrel vs. no-clopidogrel)
|
||
|---|---|---|---|---|
| Odds ratio | p value | Odds ratio | p value | |
| Any symptoms | 1.98 | <0.0001 | 1.18 | 0.4137 |
| Epigastric pain | 1.71 | 0.0005 | 2.03 | 0.0328 |
| Generalized abdominal pain | 1.88 | <0.0001 | 1.07 | 0.868 |
| Abdominal pain in left upper quadrant | 1.34 | 0.3033 | 1.11 | 0.871 |
| Abdominal pain in left lower quadrant | 1.46 | 0.0466 | 0.47 | 0.2115 |
| Abdominal pain of other specific site | 1.81 | <0.0001 | 1.64 | 0.0862 |
| Periumbilical pain | 1.93 | 0.0647 | N/A | N/A |
| Abdominal pain in right lower quadrant | 1.30 | 0.2012 | 0.81 | 0.702 |
| Abdominal pain in right upper quadrant | 1.39 | 0.999 | 1.01 | 0.9802 |
| Abdominal pain in unspecified site | 1.34 | 0.0426 | 1.13 | 0.6497 |
| Epigastric abdominal tenderness | 5.46 | 0.0464 | N/A | N/A |
| Abdominal pain | 0.37 | 0.3328 | N/A | N/A |
| Acute gastritis without hemorrhage | 3.19 | 0.0013 | N/A | N/A |
| Acute pain NEC | 2.90 | <0.0001 | N/A | N/A |
| Anal or rectal pain | 1.15 | 0.7578 | 0.57 | 0.5861 |
| Constipation | 1.32 | 0.2615 | 1.15 | 0.8053 |
| Constipation NEC | 2.65 | 0.0001 | 2.97 | 0.0723 |
| Constipation NOS | 1.88 | <0.0001 | 1.27 | 0.4244 |
| Diarrhea | 1.35 | 0.0277 | 1.07 | 0.7946 |
| Flatulence/eructation/gas pain | 0.89 | 0.6934 | 1.20 | 0.712 |
| Gastritis/duodenitis NOS | 1.90 | 0.5771 | N/A | N/A |
| Gastroduodenal disease NEC | 1.99 | 0.0007 | 1.39 | 0.3759 |
| Gastroduodenal disease NOS | 2.16 | 0.0157 | 2.84 | 0.0827 |
| Gastroparesis | 2.92 | <0.0001 | 2.20 | 0.0494 |
| Infectious diarrhea NOS | 1.54 | 0.6912 | 5.18 | 0.1991 |
| Noninfectious gastroenteritis NEC | 1.64 | 0.0039 | 0.54 | 0.1184 |
| Psychogenic pain NEC | 5.85 | 0.1485 | N/A | N/A |
| Psychogenic pain NOS | 29.41 | 0.0006 | N/A | N/A |
Bold values are statistically significant (p < 0.05)
N/A, insufficient data to calculate significance. Some outcomes were not included in the table because of insufficient data. These include slow transit constipation, gastric anomaly, NEC, gastritis with hemorrhage, functional diarrhea, diarrhea of infectious origin, adverse effects— antidiarrheal agent