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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Mol Cancer Ther. 2017 Jul 17;16(10):2069–2082. doi: 10.1158/1535-7163.MCT-17-0141

Figure 1.

Figure 1.

PI3K/AKT and NOTCH1 pathways are co-activated in Lmo2 driven T-ALL in mice. A, Kaplan-Meier survival curves for CD2-Lmo2 transgenic animals. Representative immunoblots of the primary T-ALL cells from diseased mice showing protein expression of PTEN and cMYC as well as AKT and NOTCH1 activation state (B), and expression of p110 catalytic subunits of class I PI3K (C). D, Expression levels of Notch1 and its target Deltex1 in primary murine tumors compared to wild-type (WT) DN3 thymocytes as determined by qRT-PCR (n = 7). ***, P < 0.0001; ns = not significant.