Fig 1.

Disposition of patients in the study. (*) Of the 76 patients who were not randomly assigned, 57 did not meet eligibility criteria. (†) Ninety-one patients in the talimogene laherparepvec plus ipilimumab arm received at least one dose of both study treatments. (‡) Eight patients were enrolled in the study but did not receive any study medication: talimogene laherparepvec plus ipilimumab (n = 3); ipilimumab alone (n = 5). All but one patient withdrew consent before treatment began; the remaining patient withdrew for insurance reasons. All were included in the intent-to-treat analysis of efficacy.