Table 2.
Hazard ratios, 95% CIs, and p values for risk of mortality per standard deviation disadvantage in AH4 score and reaction times.
| Unadjusted |
Sex, smoking, SES adjusted |
Fully adjusted |
Selected |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cause of Death | Predictor | Hazard ratio | 95% CI | p | Hazard ratio | 95% CI | p | hazard ratio | 95% CI | p | Hazard ratio | 95% CI | p |
| All Cause | AH4 | 1.29 | 1.20 to 1.38 | <.001 | 1.23 | 1.13 to 1.33 | <.001 | 1.13 | 1.03 to 1.23 | 0.008 | 1.13 | 1.03 to 1.24 | 0.008 |
| CRT mean | 1.30 | 1.22 to 1.38 | <.001 | 1.24 | 1.15 to 1.33 | <.001 | 1.08 | 0.96 to 1.21 | 0.186 | 1.13 | 1.04 to 1.23 | 0.005 | |
| SRT mean | 1.23 | 1.15 to 1.31 | <.001 | 1.21 | 1.14 to 1.30 | <.001 | 1.08 | 0.97 to 1.20 | 0.151 | ||||
| CRT SD | 1.12 | 1.05 to 1.20 | 0.001 | 1.11 | 1.03 to 1.19 | 0.003 | 1.02 | 0.94 to 1.11 | 0.632 | ||||
| SRT SD | 1.18 | 1.11 to 1.26 | <.001 | 1.18 | 1.10 to 1.26 | <.001 | 1.06 | 0.97 to 1.16 | 0.178 | 1.10 | 1.02 to 1.18 | 0.015 | |
| CVD | AH4 | 1.30 | 1.15 to 1.48 | <.001 | 1.27 | 1.10 to 1.47 | <.001 | 1.19 | 1.02 to 1.39 | 0.027 | 1.22 | 1.05 to 1.41 | 0.008 |
| CRT mean | 1.29 | 1.15 to 1.44 | <.001 | 1.22 | 1.08 to 1.39 | 0.002 | 1.01 | 0.83 to 1.23 | 0.947 | ||||
| SRT mean | 1.21 | 1.08 to 1.35 | <.001 | 1.20 | 1.07 to 1.35 | 0.002 | 1.09 | 0.91 to 1.31 | 0.324 | 1.14 | 1.01 to 1.29 | 0.037 | |
| CRT SD | 1.13 | 1.01 to 1.27 | 0.039 | 1.16 | 1.03 to 1.30 | 0.013 | 1.09 | 0.95 to 1.25 | 0.221 | ||||
| SRT SD | 1.16 | 1.03 to 1.30 | 0.011 | 1.16 | 1.04 to 1.31 | 0.011 | 1.04 | 0.89 to 1.21 | 0.640 | ||||
| CHD | AH4 | 1.35 | 1.15 to 1.59 | <.001 | 1.30 | 1.08 to 1.56 | 0.006 | 1.17 | 0.96 to 1.43 | 0.119 | 1.24 | 1.03 to 1.49 | 0.023 |
| CRT mean | 1.35 | 1.18 to 1.55 | <.001 | 1.29 | 1.11 to 1.51 | <.001 | 1.05 | 0.82 to 1.34 | 0.713 | ||||
| SRT mean | 1.25 | 1.09 to 1.43 | 0.002 | 1.23 | 1.07 to 1.42 | 0.005 | 1.07 | 0.86 to 1.35 | 0.539 | ||||
| CRT SD | 1.19 | 1.03 to 1.38 | 0.020 | 1.22 | 1.06 to 1.41 | 0.006 | 1.12 | 0.94 to 1.34 | 0.189 | 1.18 | 1.02 to 1.36 | 0.030 | |
| SRT SD | 1.21 | 1.05 to 1.39 | 0.008 | 1.21 | 1.05 to 1.40 | 0.008 | 1.07 | 0.88 to 1.30 | 0.502 | ||||
| Stroke | AH4 | 1.08 | 0.84 to 1.38 | 0.551 | 1.01 | 0.76 to 1.33 | 0.968 | 1.00 | 0.73 to 1.35 | 0.975 | |||
| CRT mean | 1.10 | 0.85 to 1.43 | 0.469 | 1.02 | 0.76 to 1.37 | 0.897 | 1.00 | 0.66 to 1.53 | 0.984 | ||||
| SRT mean | 1.08 | 0.83 to 1.40 | 0.589 | 1.06 | 0.81 to 1.39 | 0.672 | 1.07 | 0.72 to 1.59 | 0.724 | ||||
| CRT SD | 0.95 | 0.73 to 1.24 | 0.716 | 0.97 | 0.75 to 1.26 | 0.821 | 0.96 | 0.71 to 1.30 | 0.802 | ||||
| SRT SD | 1.02 | 0.79 to 1.32 | 0.875 | 1.02 | 0.78 to 1.33 | 0.871 | 0.99 | 0.71 to 1.38 | 0.948 | ||||
| Cancer: all | AH4 | 1.20 | 1.07 to 1.36 | 0.002 | 1.13 | 0.99 to 1.30 | 0.073 | 1.12 | 0.96 to 1.30 | 0.142 | |||
| CRT mean | 1.13 | 0.99 to 1.27 | 0.061 | 1.05 | 0.92 to 1.21 | 0.449 | 0.91 | 0.75 to 1.11 | 0.351 | ||||
| SRT mean | 1.18 | 1.05 to 1.32 | 0.005 | 1.16 | 1.03 to 1.30 | 0.015 | 1.16 | 0.97 to 1.38 | 0.106 | 1.16 | 1.03 to 1.30 | 0.015 | |
| CRT SD | 1.02 | 0.90 to 1.15 | 0.751 | 0.99 | 0.87 to 1.12 | 0.828 | 0.98 | 0.85 to 1.12 | 0.733 | ||||
| SRT SD | 1.13 | 1.01 to 1.27 | 0.034 | 1.12 | 1.00 to 1.26 | 0.059 | 1.04 | 0.90 to 1.21 | 0.584 | ||||
| Cancer: smoking | AH4 | 1.28 | 1.10 to 1.49 | 0.001 | 1.13 | 0.96 to 1.35 | 0.150 | 1.11 | 0.92 to 1.34 | 0.290 | |||
| CRT mean | 1.18 | 1.02 to 1.37 | 0.025 | 1.06 | 0.90 to 1.26 | 0.466 | 0.88 | 0.69 to 1.12 | 0.310 | ||||
| SRT mean | 1.20 | 1.04 to 1.37 | 0.010 | 1.17 | 1.01 to 1.35 | 0.036 | 1.12 | 0.91 to 1.39 | 0.293 | ||||
| CRT SD | 1.09 | 0.94 to 1.26 | 0.270 | 1.04 | 0.90 to 1.20 | 0.616 | 1.03 | 0.87 to 1.22 | 0.726 | ||||
| SRT SD | 1.20 | 1.05 to 1.37 | 0.008 | 1.18 | 1.03 to 1.36 | 0.018 | 1.13 | 0.94 to 1.35 | 0.200 | 1.18 | 1.03 to 1.36 | 0.018 | |
| Cancer: other | AH4 | 1.08 | 0.88 to 1.32 | 0.453 | 1.13 | 0.90 to 1.41 | 0.291 | 1.13 | 0.88 to 1.46 | 0.322 | |||
| CRT mean | 1.02 | 0.81 to 1.27 | 0.891 | 1.04 | 0.83 to 1.31 | 0.732 | 0.97 | 0.70 to 1.35 | 0.875 | ||||
| SRT mean | 1.13 | 0.93 to 1.38 | 0.229 | 1.14 | 0.93 to 1.40 | 0.199 | 1.23 | 0.91 to 1.66 | 0.182 | ||||
| CRT SD | 0.90 | 0.72 to 1.12 | 0.331 | 0.88 | 0.70 to 1.11 | 0.275 | 0.86 | 0.67 to 1.12 | 0.266 | ||||
| SRT SD | 0.99 | 0.80 to 1.23 | 0.962 | 1.00 | 0.80 to 1.24 | 0.972 | 0.89 | 0.67 to 1.18 | 0.415 | ||||
| Respiratory | AH4 | 1.52 | 1.23 to 1.88 | <.001 | 1.38 | 1.08 to 1.77 | 0.010 | 1.16 | 0.88 to 1.52 | 0.298 | |||
| CRT mean | 1.49 | 1.27 to 1.75 | <.001 | 1.43 | 1.18 to 1.72 | <.001 | 1.41 | 1.03 to 1.94 | 0.034 | 1.27 | 1.03 to 1.57 | 0.028 | |
| SRT mean | 1.33 | 1.12 to 1.58 | 0.001 | 1.30 | 1.09 to 1.56 | 0.004 | 0.89 | 0.67 to 1.20 | 0.447 | ||||
| CRT SD | 1.10 | 0.90 to 1.35 | 0.336 | 1.05 | 0.86 to 1.29 | 0.628 | 0.84 | 0.66 to 1.06 | 0.148 | ||||
| SRT SD | 1.38 | 1.18 to 1.63 | <.001 | 1.38 | 1.17 to 1.64 | <.001 | 1.31 | 1.05 to 1.64 | 0.019 | 1.26 | 1.04 to 1.54 | 0.020 | |
| Digestive | AH4 | 1.33 | 0.97 to 1.83 | 0.079 | 1.33 | 0.92 to 1.91 | 0.127 | 1.21 | 0.81 to 1.79 | 0.354 | |||
| CRT mean | 1.32 | 0.99 to 1.75 | 0.055 | 1.28 | 0.95 to 1.74 | 0.109 | 0.92 | 0.57 to 1.50 | 0.746 | ||||
| SRT mean | 1.20 | 0.90 to 1.61 | 0.212 | 1.19 | 0.88 to 1.62 | 0.247 | 0.95 | 0.59 to 1.51 | 0.814 | ||||
| CRT SD | 1.41 | 1.09 to 1.83 | 0.010 | 1.40 | 1.08 to 1.82 | 0.012 | 1.35 | 0.97 to 1.87 | 0.073 | 1.40 | 1.08 to 1.82 | 0.012 | |
| SRT SD | 1.33 | 1.03 to 1.71 | 0.031 | 1.33 | 1.02 to 1.73 | 0.032 | 1.28 | 0.91 to 1.80 | 0.158 | ||||
| Dementia | AH4 | 1.24 | 0.89 to 1.72 | 0.198 | 1.06 | 0.73 to 1.53 | 0.750 | 0.98 | 0.66 to 1.47 | 0.940 | |||
| CRT mean | 1.28 | 0.94 to 1.74 | 0.119 | 1.20 | 0.85 to 1.69 | 0.304 | 1.27 | 0.74 to 2.19 | 0.379 | ||||
| SRT mean | 1.17 | 0.83 to 1.63 | 0.369 | 1.12 | 0.79 to 1.59 | 0.512 | 1.05 | 0.62 to 1.77 | 0.854 | ||||
| CRT SD | 1.07 | 0.77 to 1.49 | 0.675 | 1.01 | 0.72 to 1.42 | 0.963 | 0.91 | 0.61 to 1.36 | 0.662 | ||||
| SRT SD | 1.02 | 0.72 to 1.45 | 0.900 | 1.00 | 0.70 to 1.42 | 0.991 | 0.90 | 0.57 to 1.43 | 0.663 | ||||
Notes: Unadjusted and covariate adjusted results are from separate models for each cognitive variable. The fully adjusted results are for a single model (per cause) that includes the covariates and all cognitive variables. The Selected model results are derived from the fully adjusted model by backwards elimination of non-significant cognitive variables whilst retaining the covariates.
AH4 scores are reversed.