Table 1.
Patient Demographic and Tumor Characteristics at Baseline
| Characteristic | ANA Alone (n = 26) | ANA + PIC (n = 44) | ||
|---|---|---|---|---|
| No. (%) | Mean (range) | No. (%) | Mean (range) | |
| Age (years) | 68.7 (48.9-85.4) | 67.5 (49.2-83.0) | ||
| Size of primary tumor, cm | 20.2 (10-36) | 20.7 (10-50) | ||
| Tumor grade | ||||
| 1-2 | 22 (84.6) | 37 (84.1) | ||
| 3 | 4 (15.4) | 7 (15.9) | ||
| PgR status | ||||
| Positive | 16 (64.0) | 29 (95.1) | ||
| Negative | 9 (36.0) | 2 (4.9) | ||
| Molecular subtype | ||||
| Luminal A | 6 (31.6) | 14 (41.2) | ||
| Luminal B | 13 (68.4) | 20 (58.8) | ||
| Ki-67 (% positive tumor cells) | 25.0 (4.4-68.7) | 22.6 (2.7-67.8) | ||
| 0-14 | 9 (34.6) | 17 (38.6) | ||
| >14 | 17 (65.4) | 27 (61.4) | ||
| PIK3CA mutation status | ||||
| Wild-type | 14 (60.8) | 24 (60.0) | ||
| Mutation | 9 (39.1) | 16 (40.0) | ||
| Kinase domain mutation | 5 (21.7) | 9 (22.5) | ||
| Helical domain mutation | 3 (13.0) | 6 (15.0) | ||
NOTE. Kinase domain mutations include H1047R/Y, H1048R, and G1049D/R; helica -domain mutations include E524K and E545K.
Abbreviations: ANA, anastrozole; PgR, progesterone receptor; PIC, pictilisib.