Table 2.

Operational criteria for detection of clinically significant deficits cognitive and psychological function

Cognitive domain
Exclude if both of the following criteria are met
1. Evidence of lowered general cognitive function	Mini–Mental State Examination test (MMSE)	Age-adjusted MMSE ≤ 23
2. Evidence of lower than age-appropriate learning and recall of verbal information	Hopkins Verbal Learning Test (HVLT)	HVLT-total recall score ≤ 24
Psychological domain
Exclude if any of the following criteria are met
1. Increased levels of anxiety and/or lowered mood experienced over the preceding week	Hospital and Depression Scale (HADS)	HADS-a score ≥ 15 (severe symptoms) HADS-d score ≥ 15 (severe symptoms)