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. 2018 Jun 21;10:28–39. doi: 10.1016/j.omto.2018.06.002

Figure 3.

Figure 3

SMC Cotreatment with TNF-α-Armed Oncolytic VSV Induces Rapid Death of Cancer Cells

(A) Alamar blue viability assays of GM38, EMT6, and SNB75 cells treated with vehicle or 5 μM of the SMC LCL161 and increasing MOI of the indicated virus for 48 hr. Mean, SD. (B) Micrographs and quantification of DEVD-FITC signals from EMT6 and SNB75 cells treated with vehicle or 5 μM LCL161 and 1 MOI of the indicated virus. Scale bars, 50 μm. Mean, SEM. (C) SNB75 cells were transfected with non-targeting (NT), RIP1, or CASP8 siRNA for 48 hr and subsequently treated with vehicle or 5 μM LCL161 and BSA, 0.1 ng/mL TNF-α, or infected with 0.1 MOI of the indicated virus. Mean, SD.