Table 2.

Univariate and Multivariate Cox Proportional Hazard Regression Analysis of Recurrence-free Survival in Each Dataset

Variables	Univariate Analysis			Multivariate Analysis
	HR	95% CI	p Value	HR	95% CI	p Value
Discovery Dataset (n = 389)
RRLnc6 score (high/low)	2.461	1.807–3.353	<0.0001	2.043	1.488–2.806	<0.0001
Age	1.002	0.990–1.014	0.746	1.003	0.991–1.016	0.593
Gender (male/female)	1.281	0.950–1.729	0.105	1.316	0.975–1.776	0.073
Stage (III, IV/I, II)	2.588	1.900–3.524	<0.0001	2.210	1.609–3.035	<0.0001
GEO: GSE39582 Dataset (n = 574)
RRLnc6 score (high/low)	2.300	1.689–3.132	<0.0001	1.933	1.410–2.650	<0.0001
Age	0.999	0.988–1.010	0.921	1.001	0.990–1.013	0.828
Gender (male/female)	1.287	0.953–1.737	0.099	1.330	0.985–1.797	0.063
Stage (III, IV/I, II)	2.714	1.994–3.696	<0.0001	2.398	1.749–3.287	<0.0001
GEO: GSE14333 Dataset (n = 226)
RRLnc6 score (high/low)	1.767	0.997–3.134	0.051	1.673	0.943–2.968	0.079
Age	0.981	0.961–1.001	0.069	0.988	0.968–1.009	0.251
Gender (male/female)	1.101	0.629–1.924	0.737	0.965	0.543–1.718	0.905
Stage (III, IV/I, II)	3.683	2.032–6.675	<0.0001	3.455	1.893–6.304	0.0001
GEO: GSE17538 Dataset (n = 200)
RRLnc6 score (high/low)	1.831	1.067–3.141	0.028	1.816	1.052–3.132	0.032
Age	0.980	0.962–0.999	0.043	0.979	0.959–0.999	0.038
Gender (male/female)	0.750	0.441–1.276	0.289	0.645	0.368–1.130	0.125
Stage (III, IV/I, II)	1.612	0.945–2.749	0.080	1.650	0.959–2.836	0.070
GEO: GSE33113 Dataset (n = 89)
RRLnc6 score (high/low)	3.173	1.13–8.906	0.028	3.499	1.228–9.975	0.019
Age	0.980	0.946–1.015	0.254	0.971	0.936–1.007	0.118
Gender (male/female)	0.978	0.386–2.480	0.963	0.893	0.347–2.300	0.815