Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 3;8:11654. doi: 10.1038/s41598-018-30185-3

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

A schematic summary of the IVD degeneration in vitro model and effects of PBM on ECM-modifying enzymes in human NP cells. In this IVD degeneration in vitro model, macrophage THP-1 like cells express proinflammatory cytokines such as IL-1β and TNF-α. These molecules activate NF-κB downstream signaling, which control expression of inflammatory catabolic genes encoding including MMP1 and MMP3 via nucleus translocation of NF-κB (p65 and p50 subunits). Possible effect sites of PBM observed in this study are indicated by red lines. Abbreviations: IκB, inhibitor of nuclear factor κB; IL-1R1, IL-1 receptor 1; IL-1RAcP, IL-1 receptor accessory protein; NFκB, nuclear factor κB; TNF-α, tumor necrosis factor- alpha; IL-1β, interleukin-1beta; TNFR, TNF receptor 1; MMP, matrix metalloproteinase; TIMP, a tissue inhibitor of metalloproteinases.