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. 2018 Aug 3;8:11682. doi: 10.1038/s41598-018-30143-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MtDNA copy number density assessed by ddPCR. The groups represent pooled data of fibres from different patients; OPA1 group (P1 and P2); POLG group (P3 and P4); single deletion group (P5, P6 and P7); control group (C1, C2 and C3). All measurements were performed in triplicates. The mean values for each group are presented with black horizontal lines. Levels of significance: **P = 0.001–0.01; ***P < 0.001.