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. 2018 Aug 3;8:11685. doi: 10.1038/s41598-018-29763-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Metabolic mapping. Analysis of several metabolic pathways using HumanCyc: Encyclopedia of human genes and metabolism. Each enzyme in a biosynthetic pathway is depicted as a square. Changes in transcription levels are color-coded: red indicates an activated gene (P < 0.05), purple indicates a deactivated gene (P < 0.05) and grey indicates no significant change. Asterisks indicate the (predicted) rate limiting or rate regulating steps of the metabolic pathway. (A) Activity of the main ATP producing pathways in cells (B) cholesterol synthesis and lipogenesis.