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. 2018 Aug 3;9:3068. doi: 10.1038/s41467-018-05539-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Transcriptomic and translatomic analysis of non-silenced and DAP5-silenced MDA-MB-231 cells. Total mRNA; light polysome, poorly translated mRNA (2–3 ribosome fraction); and heavy polysome, well-translated mRNA (≥4 ribosome fraction) were subjected to RNAseq. Average of two independent complete studies shown. a Heat map of RNAseq-mRNAs dependent on DAP5 for well-translated fractions. The black lines indicate the average fold change per gene across the dataset. Polysome mRNAs most strongly reduced with DAP5 silencing can be found in Supplementary Data 1 for source data. b Top predicted cellular functions affected with DAP5 silencing determined by Ingenuity Pathway Analysis (IPA)