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. 2018 Aug 3;8:11678. doi: 10.1038/s41598-018-30149-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Volcano plots of differentially expressed genes (DEGs) in the liver, induced by acetaminophen (APAP). False discovery rates (FDRs) plotted against APAP-induced log₂ fold changes in DEGs for one group of rats collected at 5 h (a) and a second group at 10 h (b). Genes from the RNA-seq data mapped onto the iRno model at 5 h (c) and 10 h (d). Circles in red/green show genes/transcripts that were significantly up-/down-regulated (FDR < 0.10), whereas black circles show those that were unchanged. Cyp8b1: Cytochrome P450 family 8 subfamily B member 1; Daglb: Diacylglycerol lipase, beta; Fads1: Fatty acid desaturase 1; Fdft1: Farnesyl diphosphate farnesyl transferase 1; Hmox1: Heme oxygenase 1; Hsd17b2: Hydroxysteroid (17-beta) dehydrogenase 2; Ldlr: Low density lipoprotein receptor; Slco2a1: Solute carrier organic anion transporter family, member 2a1; Slc1a4: Solute carrier family 1 member 4; Slc25a15: Solute carrier family 25 member 15; Slc34a2: Solute carrier family 34 member 2; Tdo2: Tryptophan 2,3-dioxygenase; Tnxrd1: Thioredoxin reductase1; Upp2: Uridine phosphorylase 2.