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. 2018 Aug 3;8:11678. doi: 10.1038/s41598-018-30149-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Acetaminophen (APAP)-induced absolute flux measurements in the glucose production pathway obtained from the tracer dilution study under fasting conditions. (a) Bar graphs of flux measurements calculated from metabolic flux analysis 10 h after treatment with APAP (unfilled bars) or vehicle (filled bars). (b) Bar graph of approximate absolute flux values derived from the literature for control rats studied after 5 h of fasting^31–33 (*p < 0.05, ^#values in Hexose units and abbreviations as in Fig. 3).