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. 2018 Aug 3;8:11678. doi: 10.1038/s41598-018-30149-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Volcano plots of global plasma metabolite changes induced by acetaminophen (APAP). False discovery rates (FDRs) plotted against APAP-induced log₂ fold changes in plasma metabolites for one group of rats collected at 5 h (a) and a second group at 10 h (b). Metabolites mapped onto the iRno model based on KEGG ID annotation at 5 h (c) and 10 h (d). Red/green circles show metabolites significantly elevated/depressed (FDR < 0.10) for 5 and 10 h post APAP treatment, respectively; symbols in black show unchanged metabolites.