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. 2018 Aug 3;8:11666. doi: 10.1038/s41598-018-30094-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phenylephrine inhibits the spontaneous and oxytocin-induced contractions in mouse uterus. (a) A sample trace shows the effect of phenylephrine (PE) on spontaneous contractility in a mouse uterine ring. The left inset shows a photograph of isolated mouse uterine horns and vagina. Yellow rectangles show the two segments of uterine horns typically used for isometric tension experiments. The dose-response curve for PE-induced relaxation is shown in the right inset (N = 8, the data were presented as mean ± S.E.). (b) A sample trace depicts that PE inhibits oxytocin-induced contractions in the mouse uterine ring in a concentration-dependent manner. The corresponding dose-response curve is shown in the inset (N = 6). (c) A sample trace shows the effect of 1 μM phenylephrine (PE) on a uterine ring isolated from CO₂-anesthesized female mouse (N = 4). (d,e) Summary data for the frequency and amplitude of spontaneous contractions in uterine rings isolated from CO₂-anesthesized female mice (N = 4). (f–k) Shown are sample traces and summary data for the effect of 1 μM phenylephrine (PE) on the frequency and amplitude of spontaneous and oxytocin (100 nM)-induced contractility in uterine strips from CO₂-anesthesized female mice (N = 4). Active tension changes are shown in (a–c,f,g). The data were presented as means ± S.E. The value of “N” is the number of mice. The vertical arrows show the times where the drugs were added to the bath. OXT = oxytocin (100 nM).