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. 2018 Aug 3;8:11666. doi: 10.1038/s41598-018-30094-5

Figure 2.

Figure 2

β2-adrenoceptor antagonist prevents the PE induced relaxation of spontaneous uterine contractions. (a) A sample trace shows that prazosin has no effect on PE-induced inhibition of spontaneous contractility in a mouse uterine ring. (b) A sample trace shows that ICI118551, a β2-adrenoceptor antagonist, prevents the inhibition induced by PE in a mouse uterine ring. (c) Summary for the date shown in (a,b). DMSO (N = 5) vs ICI118551 (N = 5), *p < 0.05, **p < 0.01; ICI118,551 vs Prazosin (N = 5), #p < 0.05, ##p < 0.01. (d–g) The sample traces show that ICI118551 prevents the inhibition induced by PE in the mouse uterine strips, whereas prazosin has no effect on the PE-induced inhibition of the spontaneous contractility’s frequency and amplitude. (h,i) Summary for the data shown in (d–g). DMSO (N = 4) vs ICI118551 (N = 4), *p < 0.05, **p < 0.01; ICI118551 vs Prazosin (N = 4), #p < 0.05, ##p < 0.01. The data were presented as means ± S.E. The value of “N” is the number of mice. Active tension changes are shown in (a,b and d–g).