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. 2018 Aug 3;8:11666. doi: 10.1038/s41598-018-30094-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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β2-adrenoceptor antagonist prevented the PE-induced relaxation of the uterus in presence of oxytocin. (a–c) Sample traces show that ICI118551, a β2-adrenoceptor antagonist, prevents the inhibition induced by PE in the mouse uterine rings, whereas prazosin has no effect on the PE-induced inhibition of oxytocin-induced contractions. (d) Concentration-inhibition relationships for the data shown in (a,b). DMSO (N = 3) vs ICI118551 (n = 8), *p < 0.05, **p < 0.01; ICI118551 vs Prazosin (N = 8), #p < 0.05, ##p < 0.01. (e,f) Sample traces show that ICI118551 prevents the inhibition induced by PE in the mouse uterine strips, whereas prazosin has no effect on the PE-induced inhibition of oxytocin-induced contractions’ frequency and amplitude. (g,h) Concentration-inhibition relationships for the data shown in (e,f). ICI118551 (N = 4) vs Prazosin (N = 4), #p < 0.05, ##p < 0.01. The data were presented as means ± S.E. The value of “N” is the number of mice. Active tension changes are shown in (a–c,e and f).