Table 1.
Combination analysis for the cytotoxicity of TQ and GCB against MCF-7 and T47D breast cancer cell lines.
| Exposure time | MCF-7 | T47D | ||
|---|---|---|---|---|
| 24 h | IC50 (µM) | R-value (%) | IC50 (µM) | R-value (%) |
| GCB | 32.6 ± 3.6 | 2.7 ± 0.6 | 7.6 ± 0.7 | 6.5 ± 0.5 |
| TQ | 80.1 ± 9.8 | 55.5 ± 1.2 | >100 | N/A |
| GCB + TQ | 3.4 ± 1.3 | 0.1 ± 0.03 | 0.3 ± 0.02 | 4.3 ± 0.2 |
| CI-value | Synergism/0.53 | Synergism/less than 0.34 | ||
| 48 h | ||||
| GCB | 32.2 ± 1.1 | 0.5 ± 0.1 | 6.4 ± 1.4 | 2.3 ± 0.5 |
| TQ | 32.7 ± 1.1 | 1.2 ± 0.5 | 104 ± 3.7 | N/A |
| GCB + TQ | 3.6 ± 0.7 | 0.9 ± 0.1 | 0.27 ± 0.07 | 1.8 ± 0.4 |
| CI-value | Synergism/0.22 | Synergism/0.1 | ||
| 72 h | ||||
| GCB | 0.9 ± 0.18 | 0 | 14.3 ± 2.8 | 3.2 ± 4.5 |
| TQ | 64.9 ± 14.5 | 1.6 ± 1.3 | 165.1 ± 2.8 | 0. 1 ± 0.15 |
| GCB + TQ | 0.06 ± 0.01 | 0 | 2.3 ± 0.2 | 0 |
| CI-value | Synergism/0.15 | Synergism/0.25 | ||
Data is presented as mean ± SD; n = 3.