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. 2018 Aug 3;8:11707. doi: 10.1038/s41598-018-30102-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HSC70 expression in 5XFAD mouse cortex was drastically reduced by diosgenin administration. Diosgenin (0.1 µmol/kg/day, p.o.) or vehicle solution was administered to wild-type and 5XFAD mice (male, 5–6 months old) for 15 days. (A) On the last day of administration, an object recognition memory test was performed. The preferential indexes of the training and test session are shown. *p < 0.05 vs 5XFAD/Veh, two-tailed one-way ANOVA post hoc Dunnett’s test, ^##p < 0.01, ^###p < 0.001 vs 50%, two-tailed one sample t-test, n = 4 mice. (B) Cortex lysates were prepared, and the protein expression levels were compared on 2D-PAGE for each mouse. (C) Magnified images of the sections indicated by the red arrows in (B). This protein was more highly expressed in 5XFAD mice than in wild-type mice, but its expression was drastically decreased by diosgenin administration. This spot was cut out for MS analysis. (D) Quantitative value of the expression levels of the spot.