Table 2.
Invasive Hemodynamic and Cardiopulmonary Exercise Data
| Rest | Peak Exercise | |||||
|---|---|---|---|---|---|---|
| Control (n=72) | HFpEF (n=134) | p value | Control (n=72) | HFpEF (n=134) | p value | |
| Vital Signs | ||||||
| HR | 67±13 | 63±13 | 0.02 | 109±26 | 100±22 | 0.005 |
| SBP | 139±26 | 148±30 | 0.1 | 168±38 | 179±35 | 0.2 |
| MBP | 95±17 | 100±17 | 0.1 | 106±20 | 116±20 | 0.02 |
|
| ||||||
| Central Hemodynamics | ||||||
| Right atrial pressure mmHg | 5±2 | 9±3 | <0.0001 | 7±5 | 18±6 | <0.0001 |
| PA mean pressure, mmHg | 16±4 | 25±8 | <0.0001 | 25±8 | 45±10 | <0.0001 |
| PASP, mmHg | 28±7 | 39±11 | <0.0001 | 41±13 | 63±14 | <0.0001 |
| PCWP, mmHg | 9±4 | 16±6 | <0.0001 | 14±5 | 31±6 | <0.0001 |
| PCWP/Watts, mmHg/W | - | - | - | 0.2 ± 0.2 | 0.9 ± 0.4 | <0.0001 |
|
| ||||||
| O2 Delivery & Metabolism | ||||||
| Peak Watts achieved, W | - | - | - | 67 ± 29 | 40 ± 18 | <0.0001 |
| O2 consumption, ml/min | 222±60 | 225±61 | 0.8 | 979±350 | 812±270 | 0.002 |
| O2 consumption, ml/kg/min | 2.7±0.6 | 2.5±0.6 | 0.01 | 12.5±4.7 | 9.1±2.8 | <0.0001 |
| Cardiac output, L/min | 5.4±1.6 | 4.9±1.4 | 0.04 | 10.4±3.2 | 8.4±3.0 | <0.0001 |
| Cardiac index, L/min/m2 | 2.80±0.72 | 2.49±0.67 | 0.003 | 5.42±1.54 | 4.21±1.40 | <0.0001 |
| Stroke volume index, ml/m2 | 43±10 | 41±12 | 0.3 | 50±16 | 43±17 | 0.02 |
| AVDO2, ml/dl | 4.2±0.8 | 4.7±0.9 | 0.0001 | 9.6±2.1 | 10.0±2.2 | 0.2 |
Values are mean ± SD, %. Adjustment of multiple hypothesis testing was not performed. HR-heart rate; SBP-systolic blood pressure; MBP-mean BP; PA-Pulmonary artery; PASP-PA systolic pressure; PCWP- pulmonary capillary wedge pressure; W-Watts; AVDO2-arteriovenous O2 content difference.