Table 3.

Noninvasive Cardiopulmonary Exercise Data

	Control (n=72)	HFpEF (n=134)	p value
Vital Signs
Baseline HR, min−1	77±14	73±13	0.02
Peak HR, min−1	142±27	118±20	<0.0001
HR recovery, min−1	16±11	10±11	0.0003
Baseline systolic BP, mmHg	119±19	126±21	0.02
Peak systolic BP, mmHg	153±31	149±29	0.3
Peak Exercise capacity
Peak RER	1.14±0.11	1.14±0.13	0.7
Peak VO2, ml/min	1659±547	1334±479	<0.0001
Peak VO2, ml/kg/min	20.5±5.6	14.5±4.3	<0.0001
O2 sat, %	96±12	95±11	0.8
Breathing reserve, %	46±15	45±15	0.6
Percent Predicted peak VO2 by Wasserman formula
Peak VO2, % predicted	89±24	81±20	0.03
Peak VO2, <80% predicted, %	41	48	0.3
Peak VO2, <70% predicted, %	20	30	0.1
Peak VO2, <60% predicted, %	9	16	0.1
Peak VO2, <50% predicted, %	4	5	0.9
Percent Predicted peak VO2 by Fletcher formula
Peak VO2, % predicted	64±18	49±13	<0.0001
Peak VO2, <80% predicted, %	80	97	<0.0001
Peak VO2, <70% predicted, %	71	92	0.0001
Peak VO2, <60% predicted, %	44	78	<0.0001
Peak VO2, <50% predicted, %	23	54	<0.0001
Other Expired Gas Variables
Peak O2 pulse, ml/min/beat	12±3	11±3	0.4
VO2 at VT, ml/min	1205±383	985±361	<0.0001
VO2 at VT, ml/kg/min	14.9±4.0	10.8±3.3	<0.0001
VT percent of peak VO2, %	74±9	75±13	0.4
VE/VCO2 nadir	30±5	31±5	0.2

Values represent mean ± standard deviation. Adjustment of multiple hypothesis testing was not performed. HR- Heart Rate, FVC-Forced Vital Capacity, FEV1-Fraction of Forced Vital Capacity Expired in the first second, MVV-Maximum Voluntary Ventilation, VT-Tidal Volume, VE-Minute Ventilation, ETCO2-End Tidal Carbon Dioxide, O2-Oxygen, RR-Respiratory Rate, RER- Respiratory Exchange Ratio, VD/VT –Ratio of physiological dead space to tidal volume, RER- Respiratory Exchange Ratio. VO2 –Oxygen Consumption, VCO2 –Carbon Dioxide Production, BP-Blood Pressure, AT-Anaerobic Threshold