. Author manuscript; available in PMC: 2019 Aug 1.

Published in final edited form as: JACC Heart Fail. 2018 May 23;6(8):665–675. doi: 10.1016/j.jchf.2018.03.003

Table 5.

Noninvasive Cardiopulmonary Exercise Test predictors of HFpEF

Univariate	OR [95% CI]	AUC	Sensitivity	Specificity	p value
Age>60 years	7.5 [4.0–14.4]	0.7256	80	35	<0.0001
Chronotropic incompetence	2.2 [1.2–4.0]	0.5935	69	49	0.009
HR recovery <6 beats/min	4.2 [1.9–10.8]	0.6081	31	90	0.001

VO₂ at AT<9 ml/kg/min	6.1 [2.3–21.2]	0.6091	28	94	0.001
VO₂ at AT<11 ml/kg/min	6.8 [3.3–15.1]	0.6957	54	85	<0.0001
O₂ pulse < 0.14 ml/beat/kg	3.2 [1.8–6.0]	0.6371	73	54	0.0001
V_E/VCO₂>30	1.1 [0.6–2.0]	0.5112	48	50	0.8
V_E/VCO₂>36	1.7 [0.7–4.4]	0.5284	16	90	0.3

Peak VO₂/kg
Peak VO₂<14 ml/kg/min	10.7 [4.6–29.1]	0.7071	50	91	<0.0001
Peak VO₂<20 ml/kg/min	8.1 [4.0–17.2]	0.6906	90	49	<0.0001
Peak VO₂<17 ml/kg/min	12.4 [6.2–24.6]	0.7778	80	76	<0.0001

% Pred (Wasserman)
Peak VO₂<50% predicted	1.1 [0.3–5.1]	0.5012	5	96	0.9
Peak VO₂<60% predicted	2.0 [0.8–5.7]	0.5367	16	91	0.1
Peak VO₂<70% predicted	1.7 [0.8–3.4]	0.5474	30	80	0.1
Peak VO₂<80% predicted	1.4 [0.8–2.5]	0.5376	48	59	0.3

% Pred (Fletcher)
Peak VO₂<50% predicted	3.9 [2.1–7.7]	0.6544	54	77	<0.0001
Peak VO₂<60% predicted	4.6 [2.5–8.6]	0.6704	78	56	<0.0001
Peak VO₂<70% predicted	4.5 [2.0–10.3]	0.6018	92	29	0.0002
Peak VO₂<80% predicted	8.1 [2.8–29.7]	0.5851	97	20	<0.0001

OR-Odds Ratio, AUC-Area Under the Curve, HR-heart rate, AT-Anaerobic Threshold, VO2-Oxygen Consumption, V_E/VCO₂-ventilatory efficiency