Table 2.

Association of obesity-related traits with heart failure subtypes in sex-pooled analyses

Predictor	Outcome	HR	Multivariable-adjusted 95% CI	P
BMI	Incident HFpEF	1.34*	(1.24 – 1.45)	<0.0001
	Incident HFrEF	1.18	(1.10 – 1.27)	<0.0001
WC	Incident HFpEF	1.32	(1.22 – 1.44)	<0.0001
	Incident HFrEF	1.19	(1.10 – 1.29)	<0.0001
WHR	Incident HFpEF	1.19	(1.10 – 1.29)	<0.0001
	Incident HFrEF	1.14	(1.06 – 1.22)	0.001
HOMA-IR	Incident HFpEF	1.20*	(1.05 – 1.37)	0.006
	Incident HFrEF	0.99	(0.88 – 1.11)	0.81
TG/HDL ratio	Incident HFpEF	1.06	(0.96 – 1.17)	0.27
	Incident HFrEF	1.13	(1.04 – 1.23)	0.003
Fasting glucose	Incident HFpEF	1.15	(1.08 – 1.23)	<0.0001
	Incident HFrEF	1.07	(0.99 – 1.16)	0.08
SBP	Incident HFpEF	1.20	(1.11 – 1.20)	<0.0001
	Incident HFrEF	1.19	(1.11 – 1.27)	<0.0001

^*P for difference <0.05 using Lunn-McNeil method to compare HR for HFpEF versus HFrEF

BMI, body mass index; WC, waist circumference; WHR, waist-to-hip ratio; HOMA-IR, homeostatic model assessment of insulin resistance; TG/HDL ratio, triglyceride-to-high density lipoprotein ratio; SBP, systolic blood pressure.

Hazard ratio per 1- standard deviation increase in continuous predictor

HOMA-IR, triglycerides, and TG/HDL ratio were log-transformed

The multivariable model was adjusted for age, sex, SBP (except SBP analyses), hypertension treatment, diabetes, smoking, prevalent myocardial infarction, TC, HDL (except TG/HDL analyses), left bundle branch block or left ventricular hypertrophy. HOMA-IR analyses excluded participants with diabetes.