Table 3.
Association of obesity related traits and incident heart failure subtypes among men and women
| Predictor | Outcome | Men Multivariable-adjusted |
Women Multivariable-adjusted |
Pinteraction sex*covariate |
||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |||
| BMI | Incident HFpEF | 1.34 | (1.18 – 1.52) | <0.0001 | 1.38* | (1.24 – 1.54) | <0.0001 | 0.37 |
| Incident HFrEF | 1.24 | (1.14 – 1.35) | <0.0001 | 1.09 | (0.96 – 1.24) | 0.18 | 0.03 | |
| WC | Incident HFpEF | 1.31 | (1.16 – 1.49) | <0.0001 | 1.35* | (1.20 – 1.51) | <0.0001 | 0.42 |
| Incident HFrEF | 1.23 | (1.13 – 1.33) | <0.0001 | 1.11 | (0.96 – 1.27) | 0.15 | 0.09 | |
| WHR | Incident HFpEF | 1.17 | (1.11 – 1.24) | <0.0001 | 1.17 | (1.06 – 1.30) | 0.003 | 0.42 |
| Incident HFrEF | 1.13 | (1.06 – 1.20) | 0.0003 | 1.07 | (0.94 – 1.21) | 0.32 | 0.40 | |
| HOMA-IR | Incident HFpEF | 1.24* | (1.02 – 1.51) | 0.03 | 1.17 | (0.98 – 1.39) | 0.08 | 0.65 |
| Incident HFrEF | 1.02 | (0.89 – 1.17) | 0.78 | 0.88 | (0.71 – 1.11) | 0.29 | 0.44 | |
| Log-TG | Incident HFpEF | 0.88 | (0.75 – 1.04) | 0.14 | 1.08 | (0.94 – 1.26) | 0.29 | 0.23 |
| Incident HFrEF | 0.98 | (0.87 – 1.09) | 0.68 | 1.08 | (0.92 – 1.26) | 0.34 | 0.18 | |
| HDL | Incident HFpEF | 0.93 | (0.83 – 1.05) | 0.26 | 0.93 | (0.84 – 1.04) | 0.21 | 0.83 |
| Incident HFrEF | 0.88 | (0.81 – 0.97) | 0.01 | 0.87 | (0.76 – 1.00) | 0.05 | 0.91 | |
| Fasting | Incident HFpEF | 1.10 | (0.97 – 1.20) | 0.12 | 1.17 | (1.08 – 1.26) | <0.0001 | 0.14 |
| glucose | Incident HFrEF | 1.07 | (0.98 – 1.17) | 0.12 | 1.08 | (0.92 – 1.26) | 0.36 | 0.15 |
| SBP | Incident HFpEF | 1.18 | (1.06 – 1.32) | 0.003 | 1.21 | (1.09 – 1.35) | 0.001 | 0.49 |
| Incident HFrEF | 1.13 | (1.04 – 1.23) | 0.006 | 1.28 | (1.14 – 1.44) | <0.0001 | 0.048 | |
P for difference <0.05 using Lunn-McNeil method to compare HR for HFpEF versus HFrEF
BMI, body mass index; WC, waist circumference; WHR, waist-to-hip ratio; HOMA-IR, homeostatic model assessment of insulin resistance; TG/HDL ratio, triglyceride-to-high density lipoprotein ratio; SBP, systolic blood pressure.
Hazard ratios are reported as 1 standard deviation increase in continuous predictor.
HOMA-IR, triglycerides, and TG/HDL ratio were log-transformed.
The multivariable model was adjusted for age, SBP (except SBP analyses), hypertension treatment, diabetes, smoking, prevalent myocardial infarction, total cholesterol, HDL (except TG/HDL analyses), left bundle branch block or left ventricular hypertrophy. HOMA-IR analyses excluded participants with diabetes.