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. Author manuscript; available in PMC: 2018 Aug 15.

Published in final edited form as: Mod Pathol. 2018 Feb 15;31(7):1155–1163. doi: 10.1038/s41379-018-0034-6

Table 4.

Features of the tumor immune microenvironment and PD-L1 expression in IMTs.

	Tumor Cell PD-L1			Immune Cell PD-L1
Characteristic	Positive (n=24)	Negative (n=11)	p value^a	Positive (n=28)	Negative (n=7)	p value^a
Fusion status^b
Positive	18 (75)	10 (91)	0.31	21 (75)	7 (100)	0.30
Negative	6 (25)	1 (9)		7 (25)	0 (0)
Lymphoid aggregates	10 (42)	3 (27)	0.48	12 (43)	1 (14)	0.22
Brisk IC infiltrates
Lymphocytes	18 (75)	5 (45)	0.13	21 (75)	2 (29)	0.03
Plasma cells	13 (54)	4 (36)	0.47	15 (54)	2 (29)	0.40
Eosinophils	4 (17)	0 (0)	0.28	4 (14)	0 (0)	0.56
Neutrophils	1 (4)	0 (0)	1	1 (4)	0 (0)	1
CD8 density (cells/mm²)	378	134	0.085^c	378	94	0.008^c

^a

Fisher’s exact test unless otherwise noted

^b

Includes ALK positive and ROS1-rearranged tumors

^c

Wilcoxon rank sum test

Abbreviations: immune cells (IC)