Table 3.

Risk of mortality from HF in FHS and CHS combined from 1990–2009—excluding individuals with undetermined LVEF

	1990–1999 HR (95% CI)	P value	2000–2009 HR (95% CI)	P value	p-value for cohort interaction
Hazards for mortality between decades
HFREF (n=844)	Referent	-	0.97 (0.81, 1.15)	0.70	0.52
HFPEF (n=740)	Referent	-	0.98 (0.81, 1.19)	0.84	0.11
Hazards for mortality comparing HF subtypes
HFREF (n=844)	Referent	-	Referent	-
HFPEF (n=740)	0.87 (0.72, 1.05)	0.14	0.95 (0.80, 1.13)	0.54	0.52/0.20

Analyses adjusted for age, sex.

HF = heart failure, HR = hazard ratio, CI = confidence interval.

HFREF and HFPEF= HF with reduced (<50%) and preserved (≥50%) left ventricular ejection fraction.