Table II.
Quantitative analysis of primary studies: number of fractures, number of infections, and infection rate in all reported open fractures, in the intervention group, and in the control group; 13 patients who were not randomized and received local antibiotics are not included in this analysis
| Study (year) | All open fractures |
Intervention group (additional local antibiotics) |
Control group (systemic antibiotics only) |
p–value* | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Fractures, n | Infections, n | Infection rate, % | Fractures, n | Infections, n | Infection rate, % | Fractures, n | Infections, n | Infection rate, % | ||
| 01_Henry et al13 (1990) | 404 | 29 | 7.2 | 334 | 14 | 4.2 | 70 | 15 | 21.4 | < 0.001 |
| 02_Ostermann et al14 (1993) | 704 | 49 | 7.0 | 547 | 23 | 4.2 | 157 | 26 | 16.6 | < 0.001 |
| 03_Ostermann et al15 (1995) | 1085 | 60 | 5.5 | 845 | 31 | 3.7 | 240 | 29 | 12.1 | < 0.001 |
| 04_Keating et al16 (1996) | 78 | 6 | 7.7 | 53 | 2 | 3.8 | 25 | 4 | 16.0 | 0.079 |
| 05_Moehring et al17 (2000) | 62 | 4 | 6.5 | 24 | 2 | 8.3 | 38 | 2 | 5.3 | 0.637 |
| 06_Ziran et al20 (2004) | 28 | 7 | 25.0 | 12 | 2 | 16.7 | 16 | 5 | 31.3 | 0.662 |
| 07_Singh et al18 (2015) | 26 | 8 | 30.8 | 3 | 1 | 33.3 | 23 | 7 | 30.4 | 1 |
| 08_Lawing et al19 (2015) | 351 | 52 | 14.8 | 168 | 16 | 9.5 | 183 | 36 | 19.7 | 0.010 |
| Overall | 2738 | 215 | 7.9 | 1986 | 91 | 4.6 | 752 | 124 | 16.5 | < 0.001 |
*
Fisher’s exact test