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. 2018 Jul 26;4(7):e00707. doi: 10.1016/j.heliyon.2018.e00707

Table 2.

Incidence, duration, and prevalence of PTD and TRD stratified by database and cap on time to failure.

Database Cap Depression Type N in cohort Number of cases Incidence estimate Incidence 95% CI Mean duration (years) Prevalence estimate
CCAE N/A PTD 14,121,194 170,489 1207.32 1201.62, 1213.01 0.74 893.42
MDCD N/A PTD 1,005,864 20,814 2069.27 2041.45, 2097.09 0.56 1158.79
MDCR N/A PTD 1,742,452 13,401 769.09 756.12, 782.06 0.67 515.29



CCAE 3 months TRD 14,121,194 4,791 33.93 32.97, 34.89 1.54 52.25
MDCD 3 months TRD 1,005,864 661 65.71 60.71, 70.72 1.55 101.86
MDCR 3 months TRD 1,742,452 228 13.08 11.39, 14.78 1.61 21.07



CCAE 6 months TRD 14,121,194 7,130 50.49 49.33, 51.65 1.58 79.78
MDCD 6 months TRD 1,005,864 987 98.12 92.01, 104.24 1.57 154.06
MDCR 6 months TRD 1,742,452 320 18.36 16.36, 20.37 1.60 29.38



CCAE 24 months TRD 14,121,194 9,038 64.00 62.69, 65.32 1.71 109.44
MDCD 24 months TRD 1,005,864 1,209 120.20 113.43, 126.96 1.68 201.93
MDCR 24 months TRD 1,742,452 404 23.19 20.93, 25.45 1.73 40.11

1 Incidence/100,000 cohort members/year.

2 Prevalence/100,000 cohort members.