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. 2018 Aug 4;16:59. doi: 10.1186/s12951-018-0386-6

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Induction of protective immunity against JEV infection with α-DC-ZZ-BNC-D3. Mice were received subcutaneous injection of α-DC-ZZ-BNC-D3 at week 0, 2, and 4. a Titers of JEV-specific total IgG in sera were determined by using ELISA (N = 6, mean ± SEM). b The mice immunized with α-DC-ZZ-BNC-D3 were challenged intraperitoneally with 50-times dose of 50% lethal dose of the JEV JaGAr01 strain followed by intracerebral inoculation with PBS