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. 2018 Aug 3;16:218. doi: 10.1186/s12967-018-1590-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Function of miR-29c on macrophage in regulating Th cell differentiation. ROR-γt and GATA-3 expression were increased in CD4⁺ T cells compared to control group when CD4⁺ T cells co-cultured with macrophage transfected with anti-miR-29c. ROR-γt expression was decreased when CD4⁺ T cells co-cultured with macrophage transfected with pLenti-miR-29c. Levels of IL-4 and IL-17 in supernatants were increased in anti-miR-29c group and IL-17 was decreased in pLenti-miR-29c group. NS not significant; **P < 0.01; ***P < 0.001. Data are shown as mean ± STD