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A) Gene expression changes of CIC target genes after 4h and 24h of MEK inhibition in WT and CIC KO G144 cells (colors depict log2 fold changes between DMSO and MEKi) B) Expression changes quantified by qPCR in parental G144, one WT clone and two independent CIC KO clones. C) Growth curves measured by cell count of parental and CIC KO G144 cells during continuous MEK inhibition of mock treatment (DMSO).
