Figure 3|.

Schematic management of patients with small bowel adenocarcinomas. Treatment strategy depends on disease stage and involves en-bloc resection for locoregional disease and systemic chemotherapy for metastatic disease. All current recommendations are based on case series, retrospective reviews or non-randomized prospective trials because of an absence of any randomized data. Abbreviations: PS, performance status; 5-FU, 5-fluorouracil; FOLFOX, 5-FU, leucovorin and oxaliplatin; CAPOX, capecitabine plus oxaliplatin; FOLFIRI, 5-FU, leucovorin and irinotecan; KRAS-WT, KRAS wild-type; XRT, radiation therapy.