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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Curr Opin Chem Biol. 2018 Apr 7;45:104–112. doi: 10.1016/j.cbpa.2018.03.016

Figure 3. Advances in PAT molecular probes.

Figure 3

(a) PACT images showing that HyP-1, an NIR hypoxia-response dye, changed its absorption peak from 670 nm to 760 nm five hours after exposure to the hypoxic environment of a breast tumor in a mouse [83]. (b) PACT images of a mouse breast tumor before and 24h after i.v. injection of WS2-PEG nanosheets, showing the accumulation of WS2-PEG in the tumor region [103]. The bottom-row images show that, when exposed to 808 nm light, the photothermal effect of WS2-PEG increased the local tumor temperature by 40 °C within 5 minutes.