Table 1.
Size and Zeta Potential of NPs
| NP type | Description | z-average (d.nm) |
Polydispersity index (PI)a |
Zeta potential (mV)b |
|---|---|---|---|---|
| NP | PLGA NPc | 185 ± 11 | 0.14 ± 0.03 | −1.7 ± 0.5 |
| NP-pD | PLGA NP coated with pD | 188 ± 13 | 0.12 ± 0.02 | −2.2 ± 0.6 |
| NP/Al | PLGA NP with physisorbed | 196 ± 21 | 0.19 ± 0.03 | −2.1 ± 0.3 |
| NPxAl | PLGA NP with albumin | 161 ± 8 | 0.12 ± 0.03 | −12 ± 1 |
| NP-pD-Al | PLGA NP with albumin | 185 ± 16 | 0.08 ± 0.03 | −3.9 ± 0.3 |
| HSA | Free human serum albumin | 8.2 ± 0.2 | 0.22 ± 0.01 | −11 ± 1 |
a
Polydispersity index (PI), an estimate of the width of the particle size distribution, obtained from the cumulant analysis as described in the International Standard on DLS ISO 13321:1996 and ISO 22412:2008 (Malvern DLS technical note MRK1764−01). PI < 0.1 is considered monodisperse, and > 0.7 is very broad.
b
Zeta potential measured in 10 mM NaCl.
c
PLGA NPs made of rhodamine-labeled PLGA.
NPs: n = 7 identically and independently prepared samples (mean ± s.d.) HSA: n = 3 identically and independently prepared samples (mean ± s.d.)