Table 2.
Brain regions showing abnormal activities by acupuncture stimulation (compared with the resting state) at real or sham acupuncture points in AD patients.
| Group | Brain Regions | Activity | BA | Side | Cluster Size | MNI coordinates | T value | ||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| AD with real acupuncture point stimulation | Frontal_Inf_Oper | + | / | R | 18 | 66 | 15 | 21 | 5.54 |
| Cerebellum_Crus2 | + | / | L | 182 | -15 | -90 | -33 | 4.69 | |
| Cerebellum_Crus1 | + | / | R | 34 | 27 | -90 | -27 | 4.87 | |
| Frontal_Inf_Orb | + | 47 | R | 28 | 57 | 24 | -6 | 4.55 | |
| Lateral Globus Pallidus | + | / | L | 18 | -21 | -12 | 3 | 4.23 | |
| Rolandic_Oper | + | / | L | 98 | -57 | 9 | 0 | 4.09 | |
| Parietal_Sup | + | / | L | 18 | -30 | -72 | 57 | 3.43 | |
| Supramarginal | + | / | L | 20 | -60 | -24 | 21 | 3.40 | |
| Temporal_Mid | + | / | R | 21 | 60 | -60 | 0 | 3.15 | |
| Cuneus | - | / | R | 128 | 18 | -69 | 27 | -2.65 | |
| Pallidum | - | / | R | 38 | 21 | 0 | -6 | -2.66 | |
| Rectus | - | / | L | 45 | -12 | 30 | -18 | -2.67 | |
| Cerebellum_4_5 | - | / | L | 38 | -12 | -36 | -12 | -2.68 | |
| Occipital_Inf | - | / | R | 47 | 42 | -72 | -9 | -2.70 | |
| Putamen | - | / | L | 24 | -6 | 9 | -6 | -2.69 | |
|
| |||||||||
| AD with sham acupuncture point stimulation | Cerebellum_4_5 | + | / | R | 50 | 9 | -57 | -18 | 4.50 |
| Rolandic_Oper | + | 44 | R | 32 | 60 | 6 | 9 | 4.17 | |
| Cerebellum_4_5 | + | / | L | 22 | -15 | -33 | -24 | 4.21 | |
| Cerebellum_Crus2 | + | / | L | 18 | -9 | -87 | -33 | 4.19 | |
| Parietal_Inf | + | / | L | 19 | -45 | -48 | 39 | 3.95 | |
| Cerebellum_6 | + | / | L | 18 | -15 | -63 | -18 | 3.78 | |
| Cerebellum_4_5 | + | / | R | 50 | 9 | -57 | -18 | 4.50 | |
The peak voxel for each cluster and the corresponding name of the anatomical region are given. “+” represents increased activities during the period of acupuncture stimulation from resting state, whereas “-” represents decreased ones. BA: Brodmann area. The maximum P value for voxels was 0.01 and all surviving voxels had an adjusted P value <0.05.