Figure 1.

High fat diet induced hypercholesterolemia mouse models and fatty livers. (a) Mice body weight levels were increased significantly by high fat diet at week 16. (b) Serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels were induced by high fat diet at week 16. (c) HE staining of liver tissues showed an obvious lipid accumulation in hepatocytes of mice treated by high fat diet for 16 weeks. The images were shown as 40 times enlargement. W: week; ND: normal diet group; HFD: high fat diet group. Data were presented as mean ± SEM. ^∗p < 0.05.