Table 2. KS test significance values for the comparison of original vs. randomized distributions at different co-occurrence similarity (S) and the number of co-annotated genes (n) thresholds.

KS test statistic		Co-occurrence similarity threshold
		S > 0	S ≥ 0.1	S ≥ 0.2	S ≥ 0.3	S ≥ 0.4	S ≥ 0.5	S ≥ 0.6
# of co-annotated genes threshold	n ≥ 1	0.6882	0.6884	0.4536	0.2366	0.3921	0.3484	0.3113
	n ≥ 2	0.0423	0.0057	0.0005	0.0001	0.0002	0.0038	NaN
	n ≥ 3	0.2636	0.0045	0.0000	NaN	NaN	NaN	NaN
	n ≥ 4	0.2830	0.0039	0.0000	NaN	NaN	NaN	NaN
	n ≥ 5	0.3349	0.0105	0.0000	NaN	NaN	NaN	NaN