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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Microb Pathog. 2018 Apr 25;121:9–21. doi: 10.1016/j.micpath.2018.04.039

Table II.

Predominantly Enriched Gene Ontology Molecular Functions and Biological Processes from Upregulated Differentially Expressed Genes in Human Type I-like Alveolar Epithelial Cells after 24 hour Exposure to Bacillus anthracis spores.

GO
Domain* 		GO Term Category Description Gene
Count# 		p value
MF 0005125 Cytokine activity 9 0.0035
MF 0008009 Chemokine activity 4 0.0044
MF 0005126 Cytokine receptor binding 9 0.0055
MF 0015280 Ligand-gated sodium channel activity 2 0.0084
MF 0042379 Chemokine receptor binding 4 0.0087
MF 0032395 MHC class II receptor activity 2 0.0102
MF 0005355 Glucose transmembrane transporter activity 2 0.0121
MF 0015149 Hexose transmembrane transporter activity 2 0.0141
MF 0005272 Sodium channel activity 3 0.0154
MF 0001664 G-protein coupled receptor binding 8 0.0169
MF 0015145 Monosaccharide transmembrane transporter activity 2 0.0187
MF 0001848 Complement binding 2 0.0238
MF 0005248 Voltage-gated sodium channel activity 2 0.0353
MF 0051119 Sugar transmembrane transporter activity 2 0.0385
BP 0045089 Positive regulation of innate immune response 11 0.0001
BP 0031349 Positive regulation of defense response 13 0.0001
BP 0002221 Pattern recognition receptor signaling pathway 9 0.0002
BP 0002758 Innate immune response-activating signal transduction 9 0.0002
BP 0045088 Regulation of innate immune response 12 0.0003
BP 0002218 Activation of innate immune response 9 0.0003
BP 0006954 Inflammatory response 14 0.0010
BP 0007254 JNK cascade 5 0.0011
BP 0032648 Regulation of interferon-beta production 4 0.0015
BP 0034142 Toll-like receptor 4 signaling pathway 6 0.0026
BP 0032655 Regulation of interleukin-12 production 4 0.0038
BP 0002757 Immune response-activating signal transduction 14 0.0043
BP 0032479 Regulation of type I interferon production 6 0.0044
BP 0032728 Positive regulation of interferon-beta production 3 0.0052
BP 0010533 Regulation of activation of Janus kinase activity 2 0.0053
BP 0000910 Cytokinesis 5 0.0053
BP 0002676 Regulation of chronic inflammatory response 2 0.0068
BP 0035871 Protein K11-linked deubiquitination 2 0.0068
BP 0045075 Regulation of interleukin-12 biosynthetic process 2 0.0068
BP 0051451 Myoblast migration 2 0.0068
BP 0002274 Myeloid leukocyte activation 5 0.0076
BP 0030261 Chromosome condensation 3 0.0079
BP 0002224 Toll-like receptor signaling pathway 6 0.0080
BP 0002237 Response to molecule of bacterial origin 9 0.0081
BP 0032735 Positive regulation of interleukin-12 production 3 0.0087
*

The top 25 terms in each GO domain were selected according to p < 0.05.

*

GO, gene ontology.

*

MF, molecular function.

*

BP, biological process.

#

Gene Count is the number of genes enriched in this term.