Table 2.
Fluoride levels in Long-Evans hooded rats following drinking water exposure to fluoride
| Age | Sample | G1 | G2 | G3 (10 ppm) | G4 (20 ppm) |
|---|---|---|---|---|---|
| Weanling | Brain (μg/g) | 0.0253** ± 0.01 (n = 6) | 0.00 ± 0.0 (n = 6) | 0.0477** ± 0.01 (n = 6) | 0.0811** ± 0.04 (n = 6) |
| Femur (μg/g) | 216.7** ± 4.8 (n = 6) | 35.2 ± 1.2 (n = 6) | 235.0b ± 25.0 (n = 6) | 379.8*** ± 54.6 (n = 6) | |
| Adult | Plasma (μg/ml) | 0.018*** ± 0.003 (n = 10) | 0.001 ± 0.000 (n = 10) | 0.036*** ± 0.010 (n = 8) | 0.025*** ± 0.005 (n = 10) |
| Urine (μg/ml) | 0.59 ± 0.14 (n = 8) | 4.99** ± 0.96 (n = 8) | |||
| Brain (μg/g) | 0.35 ± 0.14 (n = 10) | 0.21 ± 0.08 (n = 10) | 0.27 ± 0.11 (n = 8) | 0.85* ± 0.24 (n = 10) | |
| Femur (μg/g) | 541.6*** ± 13.6 (n = 10) | 56.79a ± 2.1 (n = 8) | 681.2* ± 43.8 (n = 10) | 993.4*** ± 95.2 (n = 10) |
Data represents mean ± SEM
Rats were exposed from gestational day 6 to tissue collection
G1: standard chow (Teklad 2918)/RO-H20
G2: low-F chow (Teklad TD.160173)/RO-H20
G3: low-F chow (Teklad TD.160173)/10 ppm F− drinking water
G4: low-F chow (Teklad TD.160173)/20 ppm F− drinking water
bp = 0.06, *p < 0.05, **p < 0.01, ***p < 0.001 as compared to G2
aTwo outliers excluded (276.8 and 849.0 μg/g)