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Summary of research findings. Upstream signals including conditions of chronically elevated glucose levels, which promotes oxidative stress in BRIN BD11 and INS1 832/13 cells, PIASy is likely SUMOylated and can subsequently promote SUMOylation of Glis3 at Lys224 and Lys430. SUMOylation of Glis3 reduces the ability of the transcription factor to activate Ins2 transcription in the cell lines.
