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. 2018 May 3;31(3):221–227. doi: 10.1293/tox.2018-0006

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©2018 The Japanese Society of Toxicologic Pathology

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/）.

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Fig. 2. — Comparison between light microscopy and IMS analysis in the lung (A), spleen (B), and mesenteric lymph node (C) of AMD-administered rat. The images are taken from the same lesion area. The left optical images are magnified images of the right optical images (red lined square). The detection intensity of AMD, N-desethyl AMD, and representative PCs (PC 34:2 and 34:1) was relatively higher in the lesion areas where foamy macrophages and/or vacuolated lymphocytes accumulated (yellow dotted outline) compared with normal areas. Optical image (HE staining) and IMS image. Scale bar = 100 μm.