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. 2018 Jul 30;9:1604. doi: 10.3389/fimmu.2018.01604

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Copyright © 2018 Richter, Sagawe, Hecker, Küllmar, Askevold, Damm, Heldmann, Pöhlmann, Ruhrmann, Sander, Schlüter, Wilker, König, Kummer, Padberg, Hone, McIntosh, Zakrzewicz, Koch and Grau.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High levels of C-reactive protein (CRP) negatively correlate with low interleukin-1β (IL-1β) levels in trauma patients. A prospective clinical study was performed on patients suffering from multiple traumata. Plasma levels of IL-1β were measured at daily intervals from the day of admission (day 0) until day 4 after trauma and a correlation analysis was performed with CRP values obtained one day earlier. (A) IL-1β at day 1 versus CRP at day 0 (n = 36), (B) IL-1β at day 2 versus CRP at day 1 (n = 31), (C) IL-1β at day 3 versus CRP at day 2 (n = 23), and (D) IL-1β at day 4 versus CRP at day 3 (n = 21). Linear regression analysis, r = correlation coefficient, CV = coefficient of variation.