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. 2018 Jul 30;12:57. doi: 10.3389/fncir.2018.00057

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Copyright © 2018 Sagot, Li and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Severe DA denervation in the dorsal striatum in Pitx3Null mice. (A) Diagram showing the dMSN-based BG motor control circuit and the possibility that D1Rs increase dMSN spike firing. The background image shows a confocal sagittal brain section outlining the key brain structures. The red is TH stain and the green is GFP to outline the basal ganglia. (B) A 3 μm confocal section showing the intense DA innervation in the striatum in Pitx3WT mice. (C) A 3 μm confocal section showing the dorso-ventral gradient DA denervation in the striatum in Pitx3Null mice; note the severe DA denervation in the dorsal striatum.