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. 2018 Jul 30;12:57. doi: 10.3389/fncir.2018.00057

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Copyright © 2018 Sagot, Li and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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L-dopa effects on the spike firing of mixed MSNs in the dorsal striatum in DA intact WT mice and DA-denervated Pitx3Null mice. (A) L-dopa modestly increased the firing of a MSN in the dorsal striatum in DA-intact WT mouse. (B) L-dopa modestly decreased the firing of a MSN in the dorsal striatum in DA-intact WT mouse. (C) L-dopa strongly increased the firing of a MSN in the dorsal striatum in DA-denervated Pitx3Null mouse. (D) L-dopa strongly decreased the firing of a MSN in the dorsal striatum in DA-denervated Pitx3Null mouse. (E) Paired scatter plot of firing rates before-after L-dopa for all MSNs recorded in the dorsal striatum in Pitx3WT mice. Each dot represents the average firing rate of a single MSN. (F) Paired scatter plot of firing rates before-after L-dopa for all MSNs recorded in the dorsal striatum in Pitx3Null mice. Each dot represents the average firing rate of a single MSN.