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. 2018 Jul 30;9:614. doi: 10.3389/fneur.2018.00614

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Copyright © 2018 Wirth, Khomenko, Baldaranov, Kobor, Hsam, Grimm, Johannesen, Bruun, Schulte-Mattler, Greenlee and Bogdahn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Individual variability of cortical thinning in ALS patients. Z-transformed deviation of cortical thickness from age-related healthy controls (see Table 2) in all 20 individual ALS patients. Patient numbers refer to Table 1. Patients were sorted by age. Z-transformed deviations of cortical thickness were considered relevant at least one deviation from healthy controls. (A) Individual variability of cortical thickness of the left (lh, yellow) and right (rh, red) precentral ventral (PreV) and left (lh, pink) and right (rh, purple) precentral dorsal (PreD) ROIs. (B) Deviations of individual cortical thickness of the left (lh, light green) and right (rh, dark green) postcentral ventral (PoV) and the left (lh, bright blue) and right (rh, dark blue) postcentral dorsal (PoD) region in the same 20 individual patients. Precentral (A) and postcentral (B) ROIs were visualized upon the Freesurfer average brain surface. Lh, left hemisphere; Rh, right hemisphere; PreV, precentral ventral; PreD, precentral dorsal; PoV, postcentral ventral; PoD, postcentral dorsal.