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. 2018 Jul 30;9:614. doi: 10.3389/fneur.2018.00614

Figure 4.

Figure 4

Individual and long-term biomarker monitoring over at least 18 months. Arm-onset and young-onset patients (patient 1, 2) showed higher progression rates (see Table 1) than leg-onset similarly aged patients 8 and 9. Patient 9 (yellow), Patient 8 (red), Patient 2 (green), patient 1 (blue) are sorted based on the initial levels of ALSFRS-R sum scores. (A) Courses of ALSFRS-R sum scores of the four individual patients starting at different baseline values and developed differently over the measured time span. (B) Long-term courses of MUNIX scores for the left and right ADM of the same four patients. Individual long-term monitoring of cortical thickness of these four patients in the precentral ventral (PreV, C) and dorsal cortex (PreD, D) and postcentral ventral (PoV, E) and dorsal (PoD, F) cortex of both hemispheres. Individual cortical thickness is z-transformed to age-related healthy control level (see Table 2). Lh, left hemisphere; Rh, right hemisphere.